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There are several matches for 'probable exonuclease'.
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350 matches
showing page 1 of 18
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organism
protein
1)
Homo sapiens
EXO5 -
Exonuclease
V; Single-stranded DNA (ssDNA) bidirectional
exonuclease
involved in DNA repair.
Probably
involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5'
exonuclease
activities with a strong preference for 5'-ends. Acts as a sliding
exonuclease
that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3'-5'
exonuclease
activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'- directionality activity.
[a.k.a. Q9H790, XP_016857588, HPA028429]
2)
Homo sapiens
MGME1 - Mitochondrial genome maintenance
exonuclease
1; Metal-dependent single-stranded DNA (ssDNA)
exonuclease
involved in mitochondrial genome maintenance. Has preference for 5'-3'
exonuclease
activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels.
Probably
involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA- primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair. Specifically binds 5- h [...]
[a.k.a. XP_006723726.1, AK315532, AL121585]
3)
Homo sapiens
FAN1 - Fanconi-associated nuclease 1; Nuclease required for the repair of DNA interstrand cross- links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination,
probably
in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Acts as a 5'-3'
exonuclease
that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Pro [...]
[a.k.a. FAN1-207, ENST00000565280, ENST00000664837]
4)
Mus musculus
Exo5 -
Exonuclease
V; Single-stranded DNA (ssDNA) bidirectional
exonuclease
involved in DNA repair.
Probably
involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5'
exonuclease
activities with a strong preference for 5'-ends. Acts as a sliding
exonuclease
that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3'-5'
exonuclease
activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'- directionality activity (By similarity).
[a.k.a. NM_028457.2, Z4YLZ9, AK014134]
5)
Mus musculus
Mgme1 - Mitochondrial genome maintenance
exonuclease
1; Metal-dependent single-stranded DNA (ssDNA)
exonuclease
involved in mitochondrial genome maintenance. Has preference for 5'-3'
exonuclease
activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels.
Probably
involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA- primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair (By similarity). Specifi [...]
[a.k.a. BC063088, XM_006500302, 74528]
6)
Mus musculus
Fan1 - Fanconi-associated nuclease 1; Nuclease required for the repair of DNA interstrand cross- links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination,
probably
in the resolution of homologous recombination intermediates (By similarity). Not involved in DNA double-strand breaks resection. Acts as a 5'-3'
exonuclease
that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flankin [...]
[a.k.a. ENSMUSP00000130012, uc012fmp.1, FANCD2/FANCI-associated nuclease 1]
7)
Drosophila melanogaster
rad50 - DNA repair protein RAD50; Essential component of the MRN complex, a complex that possesses single-stranded DNA endonuclease and 3' to 5'
exonuclease
activities, and plays a central role in double-strand break (DSB) repair. The complex participates in processes such as DNA recombination, DNA repair, genome stability, telomere integrity and meiosis. The MRN complex may protect telomeres by facilitating recruitment of HOAP and HP1 at chromosome ends. In the complex, it mediates the ATP-binding and is
probably
required to bind DNA ends and hold them in close proximity; Belongs to the SMC f [...]
[a.k.a. FBgn0034728, rad50-PE, rad50-PD]
8)
Drosophila melanogaster
gkt -
Probable
tyrosyl-DNA phosphodiesterase; DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead- end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. May have low 3'
exonuclease
activity and may be able to remove a sin [...]
[a.k.a. FBgn0260817, gkt-PA, FBpp0077263]
9)
Caenorhabditis elegans
dis-3 -
Probable
exosome complex
exonuclease
RRP44; Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. dis-3 has both 3'-5'
exonuclease
and endonuclease activities (By similarity).
[a.k.a. C04G2.6, Protein DIS3 homolog, WBGene00001001]
10)
Caenorhabditis elegans
eri-1 - 3'-5'
exonuclease
eri-1; RNA
exonuclease
that acts as a negative regulator of RNA interference (RNAi).
Probably
acts by degrading the 3'-overhangs of short interfering RNAs (siRNAs). Its tissue specificity may help explain the inefficiency of neuronal RNAi.
[a.k.a. T07A9.5b, T07A9.5a.1, O44406]
11)
Caenorhabditis elegans
mre-11 - Double-strand break repair protein mre-11; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5'
exonuclease
activity. Also involved in meiotic DSB processing. In response to ionizing radiation,
probably
required for the association between the brc-1-brd-1 heterodimer and rad-51 and let-70 in order to activate E3-ubiquitin ligase activity of the heterodimer and induce ubiquitination at DNA damage sites. Belongs to the MRE11/RAD32 family.
[a.k.a. ZC302.1, Q23255, WBGene00003405]
12)
Caenorhabditis elegans
rad-50 - DNA repair protein rad-50; Essential component of the MRN complex, a complex that possesses single-stranded DNA endonuclease and 3' to 5'
exonuclease
activities, and plays a central role in double-strand break (DSB) repair, chromosome morphogenesis, DNA repair and meiosis. In the complex, it mediates the ATP-binding and is
probably
required to bind DNA ends and hold them in close proximity.
[a.k.a. T04H1.4b, NP_506070.1, WBGene00004296]
13)
Caenorhabditis elegans
F52C12.1 -
Probable
tyrosyl-DNA phosphodiesterase; DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead- end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. May have low 3'
exonuclease
activity and may be able to remove a sin [...]
[a.k.a. F52C12.1a, Tdpo-1, CDH93126]
14)
Chromobacterium violaceum
CV_2751 -
Probable
exonuclease
; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG0847.
[a.k.a. AAQ60420.1, AAQ60420, 24945568,
Probable exonuclease
,
probable exonuclease
, ...]
15)
Clostridium perfringens 13
sbcD -
Probable
exonuclease
; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand
exonuclease
that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family.
[a.k.a. BAB79921.1, gene:10489463, NC_003366.1,
Probable exonuclease
,
probable exonuclease
, ...]
16)
Clostridium perfringens 13
sbcC -
Probable
exonuclease
; 1175 aa, similar to >gp:CPSBCC_1 sbcC gene product from Clostridium perfringens (140 aa); 91.4% identity in 140 aa overlap; CPE0216.
[a.k.a. gene:10489464, BAB79922.1, BAB79922,
Probable exonuclease
,
probable exonuclease
, ...]
17)
Flavobacterium branchiophilum
CCB69679.1 -
Probable
exonuclease
.
[a.k.a. FBFL15_1615, G2Z1B6,
Probable exonuclease
]
18)
Flavobacterium indicum
KQS_06905 -
Probable
exonuclease
.
[a.k.a. CCG53340.1, CCG53340, H8XQP2,
Probable exonuclease
]
19)
Flavobacterium psychrophilum
FP0943 -
Probable
exonuclease
.
[a.k.a. CAL43037.1, WP_011963091.1, YP_001295851.1,
Probable exonuclease
]
20)
Oceanicola granulosus
EAR51249.1 - COG0708 Exonuclease III.
[a.k.a. OG2516_14581, Q2CEW1_OCEGH, EAR51249,
Probable exonuclease
,
probable exonuclease
, ...]
350 matches
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